GM-CSF: A MYELOID
Granulocyte-macrophage colony-stimulating factor (GM-CSF)
GM-CSF is a pro-inflammatory cytokine linked to myeloid-driven inflammation, including the hyperinflammation associated with cytokine release syndrome (CRS) or cytokine storm.
In healthy individuals, GM-CSF is barely detectable in the blood
GM-CSF is produced at sites of tissue inflammation and exerts a local inflammatory response
Unlike other colony-stimulating factors, GM-CSF is minimally involved in steady-state myelopoiesis
By serving as a signaling conduit between tissue-invading lymphocytes and myeloid cells, GM-CSF drives inflammation in both innate and adaptive immune responses.
In preclinical models, GM-CSF has been shown to be essential for the initiation of the inflammatory cascade leading to CRS
Overproduction of GM-CSF drives excessive inflammation, tissue damage, and enhances the production of other pathogenic cytokines
About Cytokine Storm
Cytokine storm is a myeloid-driven hyperinflammatory response that can result from a viral infection such as SARS-CoV-2 and can have many consequences including:
Acute lung injury
Multiple organ damage
C-reactive protein (CRP) levels at hospital admission can be used to inform clinical decision making
For US Healthcare Professionals Only
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